Scientific Researchers
Learn how to request tissue from the NeuroBioBank or browse our inventory of available samples.
Potential Donors
Learn about the crucial need for brain donation and how your gift can advance human knowledge.
The NIH NeuroBioBank is pleased to announce that genome-wide genotyping and whole genome sequence (WGS) data from 9667 subjects from the NIH NeuroBioBank inventory are now available to the biomedical research community. Please find the publicly available web page for this study in the NIMH Data Archive here. To access, search and analyze this dataset, apply for access here. Once approved, you will be able to access the data in collection #3917. There are helpful tutorials about accessing data here. If the tutorials don't answer the questions you have, you should contact NDAHelp@mail.nih.gov.
Since 2013, the NIH NeuroBioBank has catalyzed scientific discovery through the centralization of resources aimed at the collection and distribution of human post-mortem brain tissue.
Our networked brain and tissue repositories distribute thousands of samples per year to the research community studying neurological, developmental, and psychiatric disorders.
Learn more about the NIH NeuroBioBankLearn how to request tissue from the NeuroBioBank or browse our inventory of available samples.
Learn about the crucial need for brain donation and how your gift can advance human knowledge.
Somatic genomic changes in single Alzheimer's disease neurons.
Dementia in Alzheimer's disease progresses alongside neurodegeneration<sup>1-4</sup>, but the specific events that cause neuronal dysfunction and death remain poorly understood. During normal ageing, neurons progressively accumulate somatic mutation…
View the abstractIL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder.
Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the seru…
View the abstractNeurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism.
We had reported elevated serum levels of the peptide neurotensin (NT) in children with autism spectrum disorders (ASD). Here, we show that NT stimulates primary human microglia, the resident immune cells of the brain, and the immortalized cell line …
View the abstract